CD5 CAR T-Cell Therapy for r/r T-cell Lymphomas

This is a multi-center, open-label, non-randomized, single-arm clinical trial. Refractory/relapse T-NHL patients are treated with autologous and allogeneic CD5 CAR T-cell therapy. The primary objective is to prospectively evaluate the safety of CD5 CAR T cell bridging to HSCT in the treatment of r/r T-NHL. The primary endpoint is the type and incidence of dose limiting toxicity (DLT) within 21 days after CD5 CAR-T cell infusion. A total of 36 subjects is estimated to be enrolled.

Trial Details

NCT ID
NCT07022964
Phase
PHASE1 / PHASE2
Sponsor
Beijing GoBroad Hospital
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • CD5 CAR-T cells infusion
Locations (sample)
  • Beijing, China|39.9075,116.39723
  • Shanghai, China|31.22222,121.45806
  • Shanghai, China|31.22222,121.45806

Key Eligibility Criteria

  • Relapsed or refractory CD7-positive T-cell lymphomas that were treated with with standard chemotherapy, with poor prognosis from currently availabl…
  • Male or female, age 14-70;
  • Eastern Cooperative Oncology Group (ECOG) Physical Status Score 0-2;
  • life expectancy is at least 60 days;

For full eligibility, visit ClinicalTrials.gov.

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