5 fr Ultrahypofractionated WBI and SIB for Breast Cancer With Unfavorable Characteristics

This is a prospective, randomized, single-center, non-inferiority interventional clinical trial comparing whole breast irradiation (WBI) to a total dose of 26 Gy in 5 fractions with simultaneous integrated boost (SIB) to the tumor bed to a total dose of 30 Gy, and WBI to a total dose of 40.05 Gy in 15 fractions with SIB to the tumor bed to a total dose of 48 Gy (standard treatment), for young or unfavorable breast cancer patients.

Trial Details

NCT ID
NCT07020780
Phase
NA
Sponsor
IRCCS San Raffaele
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Adjuvant 5 fractions whole breast irradiation with simultaneous integrated boost to the tumor bed
Locations (sample)
  • Milan, Italy|45.46427,9.18951

Key Eligibility Criteria

  • Histological diagnosis of breast cancer
  • Patients younger than 40 years regardless of histological subtype, or patients between 40 and 70 years with lobular carcinoma, histological subtype…
  • Signed informed consent
  • Clinical stage T1-T3, Nx-N3

For full eligibility, visit ClinicalTrials.gov.

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