Partial Volume High-Dose Irradiation in Renal Cell Carcinoma for Intra-TUmoural Control ALongside Current Management

Prospective, randomised, feasibility study of patients with localised or metastatic renal cell carcinoma (RCC) comparing standard palliative dose radiotherapy to a high-dose hypofractionated regime. Primary aim • To demonstrate feasibility of a randomised study comparing high-dose hypofractionated radiotherapy versus standard palliative dose radiotherapy in localised or metastatic renal cell carcinoma The aim is to recruit a minimum of 24 patients; 12 to the control arm and 12 to the high-dose regime. 2 treatment arms, no placebo: * Control arm - standard palliative-dose radiotherapy, 30Gy

Trial Details

NCT ID
NCT06995664
Phase
NA
Sponsor
Royal Marsden NHS Foundation Trust
Status
RECRUITING
Cancer Type
Kidney Cancer
Interventions
  • radiotherapy
Locations (sample)
  • London, United Kingdom|51.50853,-0.12574

Key Eligibility Criteria

  • Histologically confirmed renal cell carcinoma (RCC) (histological confirmation of metastasis not required) or clinically consistent with RCC as per…
  • Not suitable for surgical resection, metastasectomy or ablative therapy due to tumour or patient factors
  • All extracranial sites which clinically require radiotherapy (as per clinician discretion)
  • Age ≥18 years

For full eligibility, visit ClinicalTrials.gov.

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