Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors
Phase 1/2, open-label study of ETX-636 in participants with advanced solid tumors
Trial Details
- NCT ID
- NCT06993844
- Phase
- PHASE1 / PHASE2
- Sponsor
- Ensem Therapeutics
- Status
- RECRUITING
- Cancer Type
- ER/PR Positive (Hormone Receptor Positive) Breast Cancer
- Interventions
- ETX-636 dose escalation
- ETX-636 dose escalation in combination with fulvestrant
- ETX-636 dose expansion in combination with fulvestrant
- Locations (sample)
- Newport Beach, California, United States|33.61891,-117.92895
- San Francisco, California, United States|37.77493,-122.41942
- New Haven, Connecticut, United States|41.30815,-72.92816
- Boston, Massachusetts, United States|42.35843,-71.05977
- Boston, Massachusetts, United States|42.35843,-71.05977
Key Eligibility Criteria
- Metastatic or locally advanced and unresectable solid tumor that has progressed on or after at least one available therapy.
- Tumor harboring an activating PIK3CA mutation detected in either tumor tissue or ctDNA.
- At least 1 measurable lesion or evaluable disease per RECIST v1.1.
- An ECOG performance status score of 0 or 1.
For full eligibility, visit ClinicalTrials.gov.