PROPHET Study: ctDNA-Guided Personalized Induction Immunochemotherapy for NSCLC

The goal of this clinical trial is to evaluate the clinical value of ctDNA testing in guiding the optimization of immunochemotherapy cycles during induction treatment for resectable patients with NSCLC. The main questions it aims to answer are: * Does ctDNA clearance indicate pathological complete response? * Are additional cycles of immunochemotherapy necessary for patients who have ctDNA clearance after initial cycles of treatment? Researchers will use ctDNA dynamics to guide the cycles of induction treatment to see if some patients can avoid excessive cycles of treatment.

Trial Details

NCT ID
NCT06977074
Phase
PHASE2
Sponsor
Sun Yat-sen University
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • PD-1 inhibitor
  • Platinum Doublet
Locations (sample)
  • Guangzhou, Guangdong, China|23.11667,113.25

Key Eligibility Criteria

  • Histologically/cytologically confirmed, untreated stage IIA-IIIB NSCLC (IASLC 8th edition).
  • Deemed resectable by MDT.
  • EGFR/ALK wild-type (non-squamous patients; squamous patients exempt).
  • ECOG PS 0-1.

For full eligibility, visit ClinicalTrials.gov.

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