Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer

This clinical trial tests how well ultra-hypofractionated (UF) whole breast irradiation (WBI) with lumpectomy cavity boost (CB) works in treating patients with stage I-III breast cancer. Breast conservation therapy (BCT) is the recommended treatment for patients with early stage breast cancer. BCT involves a lumpectomy followed by breast radiation. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Traditionally, WBI has been given once daily over 5-6 weeks and then those at high-risk for recurrence receive additional radiation (bo

Trial Details

NCT ID
NCT06954831
Phase
PHASE2
Sponsor
City of Hope Medical Center
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • Cone-Beam Computed Tomography
  • Hypofractionated External Beam Radiation Therapy
  • Questionnaire Administration
  • Radiation Boost
  • Whole Breast Irradiation
Locations (sample)
  • Arcadia, California, United States|34.13973,-118.03534
  • Duarte, California, United States|34.13945,-117.97729
  • Irvine, California, United States|33.66946,-117.82311
  • Lancaster, California, United States|34.69804,-118.13674
  • South Pasadena, California, United States|34.11612,-118.15035

Key Eligibility Criteria

  • Documented informed consent of the participant and/or legally authorized representative
  • Age: ≥ 40 years
  • Ability to read and understand English for questionnaires
  • Histologically confirmed breast cancer

For full eligibility, visit ClinicalTrials.gov.

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