Efficacy And Safety Of Hydroxychloroquine Combined With Methotrexate, Capecitabine And Bevacizumab Vs. Regorafenib In Participants With Refractory Metastatic Colorectal Cancer With Mutations In RAS Genes

This study will evaluate efficacy and safety of hydroxychloroquine combined with methotrexate, capecitabine and bevacizumab versus regorafenib in participants with refractory metastatic colorectal cancer with mutations in KRAS or NRAS genes. The hypotheses of this study are that a combination of hydroxychloroquine, methotrexate, capecitabine, and bevacizumab (compared to regorafenib) prolongs progression-free survival and overall survival, and also increases rates of objective responses and disease control.

Trial Details

NCT ID

NCT06949982

Phase

PHASE2

Sponsor

Sergey Orlov, MD

Status

RECRUITING

Cancer Type

Colon Cancer Colorectal Cancer

Interventions

• experimental group x-MAP
• Regorafenib (BAY 73-4506)

Locations (sample)

• Saint Petersburg, Sankt-Peterburg, Russia|59.93863,30.31413

Key Eligibility Criteria

• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
• Provide written informed consent
• Age ≥ 18 years
• Histologically confirmed diagnosis of colorectal cancer (CRC) with distant metastases.

For full eligibility, visit ClinicalTrials.gov.

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