A Study on Exploring the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases

It is planned to carry out a multicenter umbrella study to find the optimal organ combination and the best radioimmunotherapy combination pattern, so as to improve the survival of NSCLC patients with multiple metastases. At the same time, by using multimodal omics data, machine learning will be employed to construct a prediction model for the abscopal effect, and explore the immunoregulation of organ-specific radiotherapy and biomarkers of the abscopal effect. The main objective is to find the optimal organ combination and the best radioimmunotherapy combination pattern.

Trial Details

NCT ID

NCT06947694

Phase

PHASE2

Sponsor

Xinqiao Hospital of Chongqing

Status

RECRUITING

Cancer Type

Lung Cancer

Interventions

• chemotherapy + PD-1 inhibitors

Locations (sample)

• Chongqing, Chongqing Municipality, China|29.56026,106.55771

Key Eligibility Criteria

• Patient must meet all of the following inclusion criteria to be enrolled in this study:
• Non-small cell lung cancer diagnosed initially through pathological histology.
• There are 3-6 metastatic lesions.
• No brain metastasis or the lesions are stable.

For full eligibility, visit ClinicalTrials.gov.

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