Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Pilot study to determine feasibility of adding intrathecal chemotherapy and maintenance therapy after high dose chemotherapy for treatment of newly diagnosed HR-EBTs in patients less than 6 years of age.

Trial Details

NCT ID
NCT06942039
Phase
EARLY_PHASE1
Sponsor
C17 Council
Status
RECRUITING
Cancer Type
Brain Cancer
Interventions
  • Cytarabine IT
  • hydrocortisone
  • Cisplatin
  • Vincristine
  • Etoposide
  • Cyclophosphamide
Locations (sample)
  • Calgary, Alberta, Canada|51.05011,-114.08529
  • Vancouver, British Columbia, Canada|49.24966,-123.11934
  • Winnipeg, Manitoba, Canada|49.8844,-97.14704
  • Halifax, Nova Scotia, Canada|44.64269,-63.57688
  • Hamilton, Ontario, Canada|43.25011,-79.84963

Key Eligibility Criteria

  • Tumor Tissue Sample
  • Age: Patient must be aged ≥ 0 years to ≤ 6 years at the time of definitive confirmation of histologic diagnosis of eligible CNS tumor.
  • Diagnoses. Participants must have Central nervous system (CNS) HR-EBT including atypical teratoid rhabdoid tumour (ATRT), group 3 and group 4 medul…
  • Cranial and Spine MRI. A baseline MRI brain and spine with and without contrast is required for all patients. cranial MRI (with and without gadolin…

For full eligibility, visit ClinicalTrials.gov.

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