Clinical Efficacy and Safety Assessment of Breast-Conserving Surgery for Central Breast Cancer: A Prospective Randomized Controlled Trial

This study enrolled 158 patients with primary central early-stage breast cancer and randomly assigned them to two groups. The control group underwent total mastectomy (with optional prosthetic implantation or autologous tissue reconstruction), while the experimental group received breast-conserving surgery combined with radiotherapy (nipple resection with concurrent nipple reconstruction and oncoplastic surgery when nipple involvement was present; conversion to total mastectomy required for intraoperative or postoperative positive margins). The primary endpoint was local recurrence rate, with

Trial Details

NCT ID

NCT06938360

Phase

NA

Sponsor

Xijing Hospital

Status

RECRUITING

Cancer Type

Breast Cancer

Interventions

• breast-conserving surgery combined with radiotherapy

Locations (sample)

• Xi'an, Shaanxi, China|34.25833,108.92861

Key Eligibility Criteria

• Female patients aged 18-70 years with primary breast cancer;
• Histopathologically confirmed invasive breast cancer (meeting latest ASCO/CAP guidelines criteria) with:
• TNM stage T1-2;
• Nodal stage N0-1;

For full eligibility, visit ClinicalTrials.gov.

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