Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study

There are very few data in the literature on changes in inflammatory markers when lidocaine is administered perioperatively in patients with colorectal cancer. In patients undergoing surgery for colon cancer, the aim is to conduct a double-blind placebo-controlled study to determine differences in levels of pro-inflammatory markers, postoperative pain and opioid analgesic consumption in the first two days after surgery, and the time to first postoperative bowel movement. Groups of patients receiving perioperative lidocaine infusion, high dose dexamethasone or placebo will be compared.

Trial Details

NCT ID
NCT06923787
Phase
PHASE2
Sponsor
Institute of Oncology Ljubljana
Status
RECRUITING
Cancer Type
Colon Cancer Colorectal Cancer
Interventions
  • Lidocaine
  • Placebo
Locations (sample)
  • Ljubljana, Slovenia|46.05108,14.50513
  • Ljubljana, Slovenia|46.05108,14.50513

Key Eligibility Criteria

  • colon cancer of any stage of the disease for which elective laparoscopic colon resection and colonic anastomosis will be performed,
  • age of patients between 18 and 80 years,
  • low to moderate risk of anesthesia (ASA up to and including 3),
  • ability to understand the study and to sign an informed consent to participate in the study

For full eligibility, visit ClinicalTrials.gov.

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