Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1

The goal of this clinical trial is to evaluate if intensified omeprazole therapy can reduce high-output stoma (HOS) in adults undergoing ileostomy formation surgery. The main objectives of the study are: * To assess if intensified omeprazole treatment significantly reduces mean daily ileostomy output (ml/24h) during the first three postoperative days compared to standard omeprazole treatment. * To evaluate the proportion of patients meeting the criteria for high-output stoma (HOS ≥1400 ml/day) on consecutive postoperative days. * To measure the time required for stabilization of ileostomy out

Trial Details

NCT ID
NCT06917963
Phase
NA
Sponsor
Medical University of Gdansk
Status
RECRUITING
Cancer Type
Colon Cancer Colorectal Cancer
Interventions
  • Intensified intravenous omeprazole therapy (loading dose 80 mg IV, then 40 mg IV twice daily at 6:00 AM and 6:00 PM)
  • Standard intravenous omeprazole therapy (40 mg IV once daily at 6:00 AM).
Locations (sample)
  • Gdansk, Pomeranian Voivodeship, Poland|54.35227,18.64912
  • Gdynia, Poland|54.51889,18.53188

Key Eligibility Criteria

  • Adults aged 18 years or older
  • Scheduled for elective or emergency surgery requiring end or loop ileostomy formation
  • Able and willing to provide written informed consent
  • No contraindications to omeprazole use

For full eligibility, visit ClinicalTrials.gov.

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