Involvement of CDA and/or dCK Metabolizing Enzymes in the Response to Azacytidine Treatment of Patients With Hematologic Malignancies

Until now, the development of personalized medicine in oncology has relied on the use of somatic biomarkers to help therapists choose the right molecule(s) to administer, based on the genetic and molecular profile of each hematological disease. In this project, investigators propose to extend the strategy of therapeutic individualization to the field of dosage targeting. Today, azacytidine is a standard treatment for patients with acute myeloid leukemia (AML) and/or myelodysplastic syndromes (MDS), usually as monotherapy. According to the treatment regimen, azacytidine is prescribed at a stand

Trial Details

NCT ID
NCT06886425
Phase
NA
Sponsor
Assistance Publique Hopitaux De Marseille
Status
RECRUITING
Cancer Type
Leukemia
Interventions
  • genetic study
  • Pharmacokinetic study
  • Study of phenotypic activity of cytidine deaminase
Locations (sample)
  • Marseille, France|43.29695,5.38107

Key Eligibility Criteria

  • Patients over 18 years of age
  • Patients with acute myeloid leukemia
  • Patient with myelodysplastic syndrome
  • Person who has given non-opposition

For full eligibility, visit ClinicalTrials.gov.

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