A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

The purpose of this clinical trial is to compare drug combinations to learn which drugs work best to prevent graft-versus-host-disease (GVHD) in people who have received a stem cell transplant. The source of stem cells is from someone who is not related and has a different blood cell type than the study participant. The researchers will compare the new drug combination to a standard drug combination. They will also learn about the safety of each drug combination. Participants will: * Receive the standard or new drug combination after transplant * Visit the doctor's office for check-ups and t

Trial Details

NCT ID
NCT06859424
Phase
PHASE2
Sponsor
Center for International Blood and Marrow Transplant Research
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • Conditioning Regimen A
  • Conditioning Regimen B
  • Conditioning Regimen C
  • Conditioning Regimen D
  • Conditioning Regimen E
  • Hematopoietic Cell Transplantation
Locations (sample)
  • Birmingham, Alabama, United States|33.52066,-86.80249
  • Duarte, California, United States|34.13945,-117.97729
  • Palo Alto, California, United States|37.44188,-122.14302
  • Miami, Florida, United States|25.77427,-80.19366
  • Westwood, Kansas, United States|39.04056,-94.6169

Key Eligibility Criteria

  • Age 18 to \< 66 years (chemotherapy-based conditioning) or \< 61 years (TBI-based conditioning) at the time of signing informed consent
  • Patient or legally authorized representative has the ability to provide informed consent according to the applicable regulatory and institutional r…
  • Stated willingness to comply with all study procedures and availability for the duration of the study
  • Planned MAC regimen (see Table 8 in Section 7.4 for allowed MAC regimens)

For full eligibility, visit ClinicalTrials.gov.

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