A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

The purpose of this study is to find out whether mirdametinib in combination with palbociclib is an effective and safe treatment for people with metastatic, recurrent, and unresectable liposarcoma. This study will test different doses of mirdametinib in combination with a fixed dose of palbociclib to find the best safe dose for further testing.

Trial Details

NCT ID
NCT06843967
Phase
PHASE1 / PHASE2
Sponsor
Memorial Sloan Kettering Cancer Center
Status
RECRUITING
Cancer Type
Liposarcoma Sarcoma
Interventions
  • Mirdametinib
  • Palbociclib
Locations (sample)
  • Basking Ridge, New Jersey, United States|40.70621,-74.54932
  • Middletown, New Jersey, United States|40.39428,-74.11709
  • Montvale, New Jersey, United States|41.04676,-74.02292
  • Commack, New York, United States|40.84288,-73.29289
  • Harrison, New York, United States|40.96899,-73.71263

Key Eligibility Criteria

  • Phase I only:
  • A diagnosis of unresectable, recurrent, or metastatic DDLPS
  • Measurable disease as defined by RECIST 1.1
  • Phase II only:

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

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