Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

This phase I trial studies the side effects and best dose of papaverine (PPV) when given together with radiation therapy (RT) and tests how well it works in treating patients with rectal cancer that has spread to nearby tissue or lymph nodes (locally advanced). PPV is an enzyme inhibitor, and it may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. RT uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Giving PPV with RT may be safe, tolerable, and/or effective in treating patients with locally advanced rectal can

Trial Details

NCT ID
NCT06834126
Phase
PHASE1
Sponsor
City of Hope Medical Center
Status
RECRUITING
Cancer Type
Colorectal Cancer
Interventions
  • Biospecimen Collection
  • Computed Tomography
  • Consolidation Therapy
  • Functional Magnetic Resonance Imaging
  • Gastrointestinal Endoscopy
  • Magnetic Resonance Imaging
Locations (sample)
  • Duarte, California, United States|34.13945,-117.97729

Key Eligibility Criteria

  • Documented informed consent of the participant and/or legally authorized representative
  • Willingness to participate in all correlative studies: fMRI, and tissue collection of tumor and normal rectum (ribonucleic acid \[RNA\]/deoxyribonu…
  • Age: ≥ 18 years
  • Eastern Cooperative Oncology Group (ECOG) ≤ 2

For full eligibility, visit ClinicalTrials.gov.

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