Hyperthermia With Chemoradiotherapy in Rectal Cancer

The goal of this clinical trial is to evaluate the efficacy of deep regional hyperthermia in the context of radiochemotherapy followed by consolidation chemotherapy in locally advanced rectal cancer. Questions it aims to answer are: * Can surgery be avoided if the tumor completely regresses? * How high is the Local re-growth rate * Is the treatment safe? * Assessment of the Quality of life * Rate of sphincter-sparing surgery * Pathological staging, tumor downstaging * Assessment of continence during the course of therapy Participants will: Undergo radiochemotherapy with or without addition

Trial Details

NCT ID
NCT06831981
Phase
NA
Sponsor
University Hospital Tuebingen
Status
RECRUITING
Cancer Type
Colorectal Cancer
Interventions
  • Hyperthermia
  • Radiotherapy
  • Chemotherapy with 5-fluorouracil
  • Consolidation chemotherapy with FOLFOX
Locations (sample)
  • Tübingen, Baden-Wurttemberg, Germany|48.52266,9.05222
  • Tübingen, Baden-Wurttemberg, Germany|48.52266,9.05222

Key Eligibility Criteria

  • Male and female patients with histologically confirmed diagnosis of rectal cancer localized 0-12 cm from the anocutaneous line (i.e. lower and midd…
  • Indication for total neoadjuvant therapy irrespective of participation in the current study.
  • Any MRI staged rectal cancer with one of the following high-risk features:
  • cN2 (see Appendix)

For full eligibility, visit ClinicalTrials.gov.

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