7-Days Water-Only Fasting or Ketone Supplementation Trial in Prostate Cancer

Activating the immune system to kill cancer cells is a promising therapeutic strategy for some patients with cancer. Unfortunately, current immune-targeting treatments do not work for patients with prostate cancer. In animal models of cancer, fasting can reprogram the body's metabolism and immune cell function to help immune cells kill cancer cells likely by increasing ketosis. The purpose of this study is to determine whether 7 days of water-only fasting or a ketogenic very low-calorie diet or ketone supplementation is safe and feasible for patients with prostate cancer. This will help the in

Trial Details

NCT ID
NCT06826924
Phase
NA
Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • Fasting
Locations (sample)
  • Baltimore, Maryland, United States|39.29038,-76.61219

Key Eligibility Criteria

  • Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
  • Age ≥18 years
  • Diagnosis of adenocarcinoma of the prostate
  • If a soft tissue metastasis amenable to biopsy is present, then the participant must agree to biopsies.

For full eligibility, visit ClinicalTrials.gov.

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