ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu

This is a proof of principle clinical trial determining efficacy of single dose dualimmune checkpoint inhibitors to increase intra-tumoral T cells in esophageal, gastroesophageal junction, and gastric adenocarcinomas. These are subjects who have not previously been treated for their disease, who are willing to undergo biopsy procedures, who's disease has not spread to other parts of the body, who's tumors have ARID1A mutations.

Trial Details

NCT ID
NCT06824363
Phase
EARLY_PHASE1
Sponsor
University of California, Irvine
Status
RECRUITING
Cancer Type
Gastric Cancer
Interventions
  • Tremelimumab
  • Durvalumab
Locations (sample)
  • Orange, California, United States|33.78779,-117.85311

Key Eligibility Criteria

  • Non metastatic GEC including locally advanced unresectable
  • Treatment naïve
  • Histologically proven adenocarcinoma of the esophagus or the stomach with ARID1a mutation either by liquid biopsy (ctDNA) or tissue NGS/WES
  • MSI-Stable or pMMR

For full eligibility, visit ClinicalTrials.gov.

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