ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer

The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is: Does total pancreas removal improve survival without reducing quality of life compared to partial removal? The only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.

Trial Details

NCT ID
NCT06801899
Phase
NA
Sponsor
Insel Gruppe AG, University Hospital Bern
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • Total pancreatectomy (TP)
  • Partial pancreaticoduodenectomy (PD)
Locations (sample)
  • Münster, Germany|51.96236,7.62571
  • Ulm, Germany|48.39841,9.99155
  • Aarau, Switzerland|47.39254,8.04422
  • Baden, Switzerland|47.47333,8.30592
  • Basel, Switzerland|47.55839,7.57327

Key Eligibility Criteria

  • Adult patients (age ≥ 18 years) scheduled to undergo PD for highly suspected or histologically proven, resectable pancreatic ductal adenocarcinoma …
  • Suspected pancreas anastomosis at high-risk for development of a postoperative pancreatic fistula (POPF) (grade "D" according to Schuh et al. (29):…
  • Written informed consent

For full eligibility, visit ClinicalTrials.gov.

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