An Evaluation of Dose-escalation for Intrathoracic Tumours

This is a pragmatic trial with patients randomized between standard of care palliative thoracic radiation therapy (RT) vs. hypofractionated, dose-escalated, esophageal-sparing (HD-ES) intensity modulated radiation therapy (IMRT). The investigators hypothesize that the use of advanced radiation planning techniques to optimize dose to esophagus will permit the safe delivery of a modestly dose-escalated five-fraction course of palliative radiation to intrathoracic malignancies. This approach aims to deliver higher biologically effective doses while improving toxicity when compared to conventiona

Trial Details

NCT ID
NCT06794125
Phase
NA
Sponsor
Chris Goodman
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Hypofractionated Radiation Therapy
  • Radiation Therapy
Locations (sample)
  • Kelowna, British Columbia, Canada|49.88307,-119.48568
  • Saint John, New Brunswick, Canada|45.27076,-66.05616
  • London, Ontario, Canada|42.98339,-81.23304
  • Waterloo, Ontario, Canada|43.4668,-80.51639

Key Eligibility Criteria

  • Intrathoracic tumour requiring palliative radiation, either for palliation of symptoms or prevention of progression that is expected to cause sympt…
  • Willingness and ability to provide informed consent
  • Eastern Cooperative Oncology Group performance status 0-3
  • Age 18 years or older

For full eligibility, visit ClinicalTrials.gov.

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