A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Researchers are looking for new ways to treat metastatic nonsquamous non-small cell lung cancer (NSCLC) that has been treated before. Metastatic means the cancer has spread to other parts of the body. Nonsquamous means the cancer did not start in squamous cells, which are flat cells that line the inside of the lungs. Standard treatment (usual treatment) for NSCLC is surgery, then immunotherapy with or without chemotherapy after surgery. Immunotherapy is a treatment that helps the immune system fight cancer. Chemotherapy is a medicine that works to destroy cancer cells or stop them from growin

Trial Details

NCT ID
NCT06780085
Phase
PHASE2
Sponsor
Merck Sharp & Dohme LLC
Status
RECRUITING
Cancer Type
Non-Small Cell (NSCLC) Lung Cancer
Interventions
  • Raludotatug Deruxtecan
  • Ifinatamab Deruxtecan
  • Docetetaxel
  • 5-hydroxytryptamine subtype 3 receptor antagonist
  • Neurokinin-1 receptor antagonist
  • Corticosteroid
Locations (sample)
  • Lexington, Kentucky, United States|37.98869,-84.47772
  • Baltimore, Maryland, United States|39.29038,-76.61219
  • Pittsburgh, Pennsylvania, United States|40.44062,-79.99589
  • Santiago, Region M. de Santiago, Chile|-33.45694,-70.64827
  • Santiago, Region M. de Santiago, Chile|-33.45694,-70.64827

Key Eligibility Criteria

  • The main inclusion criteria include but are not limited to the following:
  • Histologically or cytologically confirmed diagnosis of Stage IV nonsquamous non-small cell lung cancer (NSCLC)
  • Documented disease progression per RECIST 1.1 after receiving an anti-programmed cell death 1 protein (PD-1)/programmed cell death ligand 1 (PD-L1)…
  • Confirmation per local test report that epidermal growth factor receptor negative (EGFR-), anaplastic lymphoma kinase negative (ALK-), c ros oncoge…

For full eligibility, visit ClinicalTrials.gov.

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