Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

This phase II trial tests how well biomarker tests on patients tumor tissue works in selecting personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC). Biomarker tests look for certain features in cancer cells that may give doctors more information about what is driving cancer and how to treat it. Based on the biomarker test results, study doctors can determine the subtype of ES-SCLC that study treatments can target. This study also tests different types of maintenance treatment for ES-SCLC with drugs durvalumab, saruparib, ceralasertib or monalizumab. Mainte

Trial Details

NCT ID
NCT06769126
Phase
PHASE2
Sponsor
SWOG Cancer Research Network
Status
RECRUITING
Cancer Type
Small Cell (SCLC) Lung Cancer
Interventions
  • Biospecimen Collection
  • Ceralasertib
  • Computed Tomography
  • Durvalumab
  • Etoposide
  • Magnetic Resonance Imaging
Locations (sample)
  • Loma Linda, California, United States|34.04835,-117.26115
  • Aurora, Colorado, United States|39.72943,-104.83192
  • Fort Collins, Colorado, United States|40.58526,-105.08442
  • Derby, Connecticut, United States|41.32065,-73.089
  • North Haven, Connecticut, United States|41.39093,-72.85954

Key Eligibility Criteria

  • STEP 1: SCREENING AND INDUCTION TREATMENT REGISTRATION: Participants must not have a prior or concurrent malignancy whose natural history or treatm…
  • STEP 1: SCREENING AND INDUCTION TREATMENT REGISTRATION: Participants must not have a history of limited stage small cell lung cancer
  • STEP 1: SCREENING AND INDUCTION TREATMENT REGISTRATION: Participants must meet 1 of the following criteria prior to step 1:
  • Treatment naïve and planning to receive frontline induction treatment with platinum plus etoposide in combination with durvalumab, OR,

For full eligibility, visit ClinicalTrials.gov.

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