Intraperitoneal Immune Checkpoint Inhibitors and Zoledronic Acids for Gastric Cancer Malignant Ascites

This study is to evaluate the safety and efficacy of intraperitoneal injection of immune checkpoint inhibitor combined with zoledronic acid for the treatment of malignant ascites in gastric cancer. This study is a phase Ib/II clinical study to evaluate the safety and efficacy of intraperitoneal injection of immune checkpoint inhibitors in combination with zoledronic acid in the treatment of malignant ascites in gastric cancer, which consists of two phases, firstly, the phase Ib safety study, which adopts the '3+3' drug-escalation experimental design, and after determining the safe and tolerab

Trial Details

NCT ID

NCT06759064

Phase

PHASE1 / PHASE2

Sponsor

Qilu Hospital of Shandong University

Status

RECRUITING

Cancer Type

Gastric Cancer

Locations (sample)

• Jinan, Shandong, China

Key Eligibility Criteria

• Gastric adenocarcinoma diagnosed pathologically;
• Malignant ascites confirmed by ascites cytology;
• Presence of ascites confirmed by CT with ascites graded as 2nd and 3rd degree (EASL guidelines and ICA consensus);
• Those aged 18-75 years;

For full eligibility, visit ClinicalTrials.gov.

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