Neoantigen-loaded DC Vaccine and Conventional Second-line Therapy for CRC Progressed After First-line Treatment

In this study, the investigators provide a combined treatment of personalized tumor neoantigen-loaded DC vaccine and conventional second-line therapy to patients with colorectal cancer (CRC) progressed after first-line treatment. The investigators observe the objective response rate (ORR), disease control rate (DCR), adverse event (AE), serious adverse event (SAE), progression-free survival (PFS), and overall survival (OS) , aiming to evaluate the effectiveness and safety of the treatment.

Trial Details

NCT ID
NCT06751940
Phase
NA
Sponsor
The First Affiliated Hospital of Nanchang University
Status
RECRUITING
Cancer Type
Colon Cancer Colorectal Cancer
Interventions
  • Conventional second-line therapy
  • Neoantigen-loaded DC vaccine
Locations (sample)
  • Nanchang, Jiangxi, China|28.68396,115.85306
  • Nanchang, Jiangxi, China|28.68396,115.85306

Key Eligibility Criteria

  • Patients with histologically or cytologically confirmed CRC;
  • At least one measurable lesion;
  • Aged 18-70, regardless of gender;
  • Disease progression after standard first-line therapy, and more than 2 weeks since the end of the last antitumor treatment;

For full eligibility, visit ClinicalTrials.gov.

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