Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

Evaluate frequency of adverse events that lead to chemotherapy discontinuation in vulnerable older adults with recurrent/metastatic PD-L1 TPS\<50% NSCLC patients who receive reduced dose chemotherapy in combination with immunotherapy.

Trial Details

NCT ID
NCT06731413
Phase
PHASE2
Sponsor
Virginia Commonwealth University
Status
RECRUITING
Cancer Type
Non-Small Cell (NSCLC) Lung Cancer
Interventions
  • Reduced Dose of Chemotherapy and Immunotherapy
Locations (sample)
  • Richmond, Virginia, United States|37.55376,-77.46026
  • Tappahannock, Virginia, United States|37.92541,-76.85913

Key Eligibility Criteria

  • Histologically or cytologically confirmed diagnosis of non-small cell lung cancer (NSCLC) (either squamous or non- squamous)
  • Stage IIIB, IIIC or IV disease OR have recurrent disease and not be candidates for curative treatment such as combined chemo-radiation
  • No previous line of treatment in the recurrent or metastatic setting. Neoadjuvant or adjuvant treatment more than 6 months before enrollment is acc…
  • Age 70 or meeting frailty definition or above at the date of signing informed consent

For full eligibility, visit ClinicalTrials.gov.

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