An Exploratory Study on the Failure of Immunotherapy With Voronib Combined With Everolimus

This single-arm exploratory study included patients with renal clear cell carcinoma who had previously received one type of immunotherapy and failed. The specific regimen was Voronib 200mg PO.QD combined with everolimus 5mg QD. 80 patients were planned to continue treatment until PD, toxicity became intolerable, patient withdrawal was informed, or medication had to be discontinued. Collect patient medication information and disease efficacy evaluation, adverse reactions. In this study, blood samples were collected 0-4 weeks before treatment, 2 months, 4 months, 6 months, 8 months of drug treat

Trial Details

NCT ID
NCT06730672
Phase
PHASE2
Sponsor
Sun Yat-sen University
Status
RECRUITING
Cancer Type
Kidney Cancer
Interventions
  • Volonib combined with Everolimus Formation
Locations (sample)
  • Guangzhou, Guangdong, China|23.11667,113.25
  • Zhengzhou, Henan, China|34.75778,113.64861

Key Eligibility Criteria

  • Clear cell carcinoma of the kidney is confirmed by pathology (histology or cytology);
  • Have received systemic anti-tumor therapy with no more than 2 targeted drugs (excluding mTOR inhibitors) and 1 immune checkpoint inhibitor and fail…
  • Not less than 3 weeks after receiving the last systemic anti-tumor therapy (chemotherapy, radiotherapy, targeted therapy, biotherapy or endocrine t…
  • ECOG score ≤ 1;

For full eligibility, visit ClinicalTrials.gov.

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