Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant

The goal of this clinical trial is to learn if locoregional therapy and immunotherapy can be used together to help patients with hepatocellular carcinoma (HCC) and macrovascular invasion achieve liver transplantation. The main questions it aims to answer are: * How many patients will achieve transplant with this treatment strategy? * What will the 5-year survival and recurrence-free survival rates be for these patients? Participants will: * Undergo a biopsy of the tumor. * Receive locoregional therapy (SBRT or Y90) followed by immunotherapy (atezolizumab and bevacizumab) 2 to 6 weeks later

Trial Details

NCT ID
NCT06725121
Phase
PHASE1 / PHASE2
Sponsor
University Health Network, Toronto
Status
RECRUITING
Cancer Type
Liver Cancer
Interventions
  • Atezolizumab & Bevacizumab
  • Yttrium-90 (Y-90)
  • Stereotactic body radiotherapy (SBRT)
Locations (sample)
  • London, Ontario, Canada|42.98339,-81.23304
  • Toronto, Ontario, Canada|43.65333,-79.38389

Key Eligibility Criteria

  • Weight \> 30 kg
  • Child Pugh Turcotte score A5 to B7
  • Macrovascular invasion (Vp1-3)
  • Total tumour volume \< 350 cm3

For full eligibility, visit ClinicalTrials.gov.

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