Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma

This is a multicenter randomized phase II trial that aims to include 160 patients with a non-metastatic (localized), inoperable pancreatic tumor. The study will take place at multiple centers across Europe. The primary objective of the study is to demonstrate superiority in progression free survival (PFS) by adding stereotactic body radiation therapy (SBRT) to chemotherapy for patients with an inoperable non-metastasized pancreatic tumor. SBRT is a radiotherapy technique (i.e. destroying cancer cells by means of ionizing irradiation) in which tumors can be irradiated with a high radiation dose

Trial Details

NCT ID
NCT06691425
Phase
NA
Sponsor
Cancer Research Antwerp
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • Stereotactic Body Radiation Therapy (SBRT)
  • Chemotherapy
Locations (sample)
  • Edegem, Antwerpen, Belgium|51.15662,4.44504
  • Wilrijk, Antwerp, Belgium|51.16734,4.39513
  • Brasschaat, Belgium|51.2912,4.49182
  • Bruges, Belgium|51.20892,3.22424
  • Genk, Belgium|50.965,5.50082

Key Eligibility Criteria

  • Participant must be over 18 years of age.
  • Participant is able and willing to provide written informed consent which includes compliance with and ability to undergo all study procedures and …
  • Either locally advanced or borderline resectable pancreatic adenocarcinoma, as confirmed by diagnostic images (CT, MRI or PET-CT scan) and based on…
  • Adequate organ function determined by the following laboratory values:

For full eligibility, visit ClinicalTrials.gov.

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