Clinical Trial of Autologous B7-H3 CAR T Cells in Reoccurent Platinum-resistant Ovarian Tumors

This is a single site, open label, Phase 1 study using a 3 + 3 dose escalation design in two cohorts of adults with recurrent, platinum-resistant ovarian tumors.

Trial Details

NCT ID
NCT06646627
Phase
PHASE1
Sponsor
Stanford University
Status
RECRUITING
Cancer Type
Ovarian Cancer
Interventions
  • B7-H3CART
Locations (sample)
  • Palo Alto, California, United States|37.44188,-122.14302

Key Eligibility Criteria

  • Disease: Histologically or cytologically confirmed diagnosis of ovarian cancer including serous, endometrioid, clear cell, mucinous, mixed epitheli…
  • Have measurable disease. Measurable disease is defined as at least 1 lesion that can be accurately measured in at least 1 dimension (longest diamet…
  • B7-H3 positive expression on malignant cells is NOT required but archival tissue must be available, or the subject must be willing to undergo tissu…
  • Age: ≥ 18 years of age

For full eligibility, visit ClinicalTrials.gov.

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