Preoperative Partial Breast Reirradiation and Repeat Breast-conserving Surgery in Patients With Recurrent Breast Cancer: the REPEAT Trial

Over the past decades, interest in second breast-conserving therapy (BCT) has increased due to, among others, advancements in radiotherapy techniques. Preoperative partial breast irradiation (PBI) is an experimental treatment for patients with low-risk primary breast cancer. This approach can downstage the tumor, and may possibly reduce toxicity and improve cosmetic outcomes compared to postoperative radiotherapy. This study aims to evaluate the feasibility of single-dose preoperative PBI and second breast-conserving surgery (BCS) for patients with an ipsilateral recurrent breast event (IRBE)

Trial Details

NCT ID

NCT06640881

Phase

PHASE2

Sponsor

Amsterdam UMC, location VUmc

Status

RECRUITING

Cancer Type

HER2 Negative Breast Cancer

Interventions

• ablative single-dose PBI

Locations (sample)

• Amsterdam, Netherlands|52.37403,4.88969

Key Eligibility Criteria

• Female ≥ 50 years with an ipsilateral invasive recurrent breast cancer event after previous breast-conserving surgery and postoperative whole breas…
• World Health Organization performance status 0-2
• Tumor size ≤ 2 cm and unifocal on MRI
• Tumor histology as assessed on biopsy:

For full eligibility, visit ClinicalTrials.gov.

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