TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas

This Phase I/II study evaluates the safety and efficacy of autologous tumor-infiltrating lymphocytes (TIL) therapy combined with Pembrolizumab (Keytruda) immunotherapy in patients with Advanced Brain Cancer including Gliomas and Meningiomas . Lifileucel (Amtagvi), the first FDA-approved TIL therapy, has demonstrated significant success in treating unresectable or metastatic melanoma by utilizing the patient's own immune cells to combat cancer. This study aims to apply a similar approach to Brain cancer. TILs will be harvested from patients' tumors, expanded in vitro, and infused back into the

Trial Details

NCT ID

NCT06640582

Phase

PHASE1 / PHASE2

Sponsor

Essen Biotech

Status

RECRUITING

Cancer Type

Glioblastoma (GBM) Brain Cancer

Interventions

Tumor Infiltrating Lymphocytes (TIL)
Cyclophosphamide
Fludarabine
Interleukin-2
Pembrolizumab

Locations (sample)

Beijing, Beijing Municipality, China|39.9075,116.39723

Key Eligibility Criteria

Age: 16 years to 90 years
Histologically diagnosed as primary/relapsed/metastasized brain glioma
Expected life span more than 3 months
Karnofsky≥60% or ECOG score 0-2

For full eligibility, visit ClinicalTrials.gov.

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