Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation

Currently, the standard of care treatment for newly diagnosed, inoperable stage III non-small cell lung cancer is radiotherapy (RT) with concurrent chemotherapy, followed by immune checkpoint inhibitors (ICI). RT is a highly effect local treatment. However, high doses of radiation used in curative settings can cause adverse side effects. The most common RT side effect in lung cancer is Radiation Induced Lung Injury (RILI), which can manifest as pneumonitis and/or pulmonary fibrosis. Lung injury can negatively impact patients' well-being and quality of life, and may lead to increased mortality.

Trial Details

NCT ID

NCT06634056

Phase

PHASE2

Sponsor

University Health Network, Toronto

Status

RECRUITING

Cancer Type

Lung Cancer

Interventions

Pentoxifylline
Placebo
α-Tocopherol

Locations (sample)

Toronto, Ontario, Canada|43.70643,-79.39864

Key Eligibility Criteria

Female and/or male aged ≥ 18 years.
Histologically confirmed diagnosis of stage III NSCLC, planned for treatment with concurrent chemoradiation and consolidation immune checkpoint inh…
Patients with ECOG performance status 0-2 within 4 weeks of randomization.
Adequate liver function (no evidence of Child-Pugh class C disease or cirrhosis) as per blood work done within 30 days of registration.

For full eligibility, visit ClinicalTrials.gov.

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