Evaluating rhPDGF-BB-Enhanced Wound Matrix for Head and Neck Reconstruction

Skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma lesions that develop on the head and neck are treated by Mohs surgery or wide local excision to remove all tumor cells and preserve the normal tissue. These surgical techniques may result in large defects requiring reconstruction to restore function and aesthetics. Rotational flaps and free flaps are techniques used to reconstruct large, complex defects that cannot be closed with sutures, staples, or glue. Older, frail patients are particularly vulnerable to complications from these procedures often le

Trial Details

NCT ID
NCT06634030
Phase
PHASE2
Sponsor
Vanderbilt University Medical Center
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • RhPDGF-BB
  • Saline
Locations (sample)
  • Nashville, Tennessee, United States|36.16589,-86.78444

Key Eligibility Criteria

  • Underwent surgery to completely remove skin cancer, either Mohs micrographic or wide local excision, that left a full-thickness surgical defect of …
  • Margins of the wound cannot be approximated or closed with stitches, sutures, staples, or glue
  • Surgeon does not plan for immediate skin graft or flap
  • Aged \>21 years old

For full eligibility, visit ClinicalTrials.gov.

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