Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

This phase II trial evaluates whether genetic testing in prostate cancer is helpful in deciding which study treatment patients are assigned. Patient cancer tissue samples are obtained from a previous surgery or biopsy procedure and tested for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) abnormalities or mutations in their cancer. Valemetostat tosylate is in a class of medications called EZH1/EZH2 inhibitors. It blocks proteins called EZH1 and EZH2, which may help slow or stop the spread of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. I

Trial Details

NCT ID
NCT06632977
Phase
PHASE2
Sponsor
Alliance for Clinical Trials in Oncology
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • Genetic testing
  • Valemetostat Tosylate
  • Magnetic Resonance Imaging
  • Computed Tomography
  • Bone scan
  • FDG-Positron Emission Tomography
Locations (sample)
  • Birmingham, Alabama, United States|33.52066,-86.80249
  • Tucson, Arizona, United States|32.22174,-110.92648
  • Chico, California, United States|39.72849,-121.83748
  • La Jolla, California, United States|32.84727,-117.2742
  • Colorado Springs, Colorado, United States|38.83388,-104.82136

Key Eligibility Criteria

  • PRE-REGISTRATION: Histological or cytological evidence of prostate cancer. Patients with variant histologies including neuroendocrine, small cell a…
  • PRE-REGISTRATION: Measurable disease and/or non-measurable metastatic disease per RECIST version 1.1.
  • PRE-REGISTRATION: Tissue procured within 12 months of pre-registration (metastatic disease preferred over primary tissue, though both are acceptabl…
  • PRE-REGISTRATION: Molecular report available performed as part of standard of care testing via any Clinical Laboratory Improvement Act (CLIA)-certi…

For full eligibility, visit ClinicalTrials.gov.

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