LND101 for Fecal Microbiota Transplantation in Combination With Immune Checkpoint Blockade in Advanced Melanoma

This study is being done to answer the following question: Can the chance of melanoma growing or spreading be lowered by receiving a treatment called LND101 for Fecal Microbiota Transplant (FMT) in addition to the usual immunotherapy treatment called Immune Checkpoint Blockade (ICB)? FMT treatment changes the bacteria in your gut called the microbiome.

Trial Details

NCT ID
NCT06623461
Phase
PHASE2
Sponsor
Canadian Cancer Trials Group
Status
RECRUITING
Cancer Type
Melanoma
Interventions
  • Standard of Care Immune Checkpoint Blockade
  • LND101
Locations (sample)
  • Abbotsford British Columbia, British Columbia, Canada|49.05798,-122.25257
  • Surrey, British Columbia, Canada|49.10635,-122.82509
  • Vancouver, British Columbia, Canada|49.24966,-123.11934
  • Hamilton, Ontario, Canada|43.25011,-79.84963
  • London, Ontario, Canada|42.98339,-81.23304

Key Eligibility Criteria

  • Participants must have a confirmed histological diagnosis of cutaneous melanoma or melanoma of unknown primary.
  • Participants must have stage IV or advanced unresectable disease.
  • No prior ICB treatment for advanced unresectable or metastatic disease. Participants may have received adjuvant or neoadjuvant ICB if last dose was…
  • Prior targeted therapy with BRAF/MEK inhibition in the adjuvant or advanced / metastatic setting is permitted if at least 2 weeks have elapsed betw…

For full eligibility, visit ClinicalTrials.gov.

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