A Phase Ib Study of Rezatapopt in Combination With Azacitidine in Patients With TP53Y220C Mutant Myeloid Malignancies (Acute Myeloid Leukemia or Myelodysplastic Syndrome)

A non-randomized phase Ib study of PC14586 (PMV therapeutics) in patients diagnosed with TP53Y220C-mutant myeloid malignancies, including AML and MDS.

Trial Details

NCT ID
NCT06616636
Phase
PHASE1
Sponsor
M.D. Anderson Cancer Center
Status
RECRUITING
Cancer Type
Leukemia
Interventions
  • Azacitidine
  • Rezatapopt
Locations (sample)
  • Tampa, Florida, United States|27.94752,-82.45843
  • Houston, Texas, United States|29.76328,-95.36327

Key Eligibility Criteria

  • Patient is ≥ 18 years of age at the time of signing the informed consent form (ICF).
  • Patient is willing and able to adhere to the study visit schedule and other protocol requirements.
  • Patient has relapsed or primary refractory AML or MDS
  • Any other comorbidity that per the investigator renders a patient inappropriate for intensive chemotherapy.

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Leukemia Trials on Trialify →