BCL-2 Inhibitors Combined with the HyperCVAD Regimen for Newly Diagnosed T-lymphoblastic Leukemia/lymphoma.

The experimental group included patients diagnosed with T-ALL/LBL (T-lymphoblastic leukemia/ lymphoma) at initial diagnosis, who received treatment with BCL-2 inhibitors combined with the Hyper CVAD regimen. The control group consisted of patients diagnosed with T-ALL/LBL from multiple centers, for whom basic information, disease information, treatment details, and efficacy data were collected. Propensity score matching was conducted with historical data (matching factors included age, gender, initial LDH levels, and the presence or absence of a large mediastinal mass at diagnosis) to compare

Trial Details

NCT ID
NCT06598722
Phase
PHASE2
Sponsor
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Status
RECRUITING
Cancer Type
Lymphoma
Interventions
  • BCL-2 inhibitors combined with the HyperCVAD regimen
  • Propensity score matching historical data
Locations (sample)
  • Shanghai, China|31.22222,121.45806

Key Eligibility Criteria

  • Liver and kidney function, as well as cardiopulmonary function, meet the following requirements:
  • Creatinine clearance (calculated using the Cockcroft-Gault formula) ≥60 mL/min; Left ventricular ejection fraction greater than 50%, with no clinic…
  • Any situation that the investigator believes would compromise participant safety or interfere with the study objectives, or any individual deemed i…

For full eligibility, visit ClinicalTrials.gov.

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