Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma

Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity. The study investigates the feasibility of this approach as measured by the number of expected out-of-field recurrencies based on the individual patient's state of disease progression and risk factors

Trial Details

NCT ID
NCT06563362
Phase
PHASE2
Sponsor
University of Zurich
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • De-escalation of irradiated volume
Locations (sample)
  • Zurich, Canton of Zurich, Switzerland|47.36667,8.55
  • Aarau, Switzerland|47.39254,8.04422
  • Bellinzona, Switzerland|46.19278,9.01703
  • Bern, Switzerland|46.94809,7.44744
  • Geneva, Switzerland|46.20222,6.14569

Key Eligibility Criteria

  • Patients with a newly diagnosed (no pre-treatment) squamous cell carcinoma of the oropharynx (i.e. tonsils, base of tongue, oropharyngeal walls, or…
  • Treatment with definitive (chemo) radiotherapy planned, with elective irradiation of the lymph nodes.
  • Age ≥ 18 years, no upper age limit.
  • ECOG performance score \< 3.

For full eligibility, visit ClinicalTrials.gov.

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