External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer

This phase I/II trial tests the safety and effectiveness of receiving external beam radiation therapy (EBRT) and brachytherapy along with chemotherapy, consisting of cisplatin and paclitaxel, and immunotherapy, consisting of bevacizumab and pembrolizumab, for the treatment of patients with stage IVB cervical cancer. EBRT is type of radiation therapy that uses a machine to aim high-energy rays at the cancer from outside of the body. Brachytherapy, also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Cisplatin is in a class

Trial Details

NCT ID
NCT06543576
Phase
PHASE1 / PHASE2
Sponsor
Jonsson Comprehensive Cancer Center
Status
RECRUITING
Cancer Type
Cervical Cancer
Interventions
  • Bevacizumab
  • Biospecimen Collection
  • Brachytherapy
  • Cisplatin
  • External Beam Radiation Therapy
  • Paclitaxel
Locations (sample)
  • Los Angeles, California, United States|34.05223,-118.24368
  • San Diego, California, United States|32.71571,-117.16472
  • Oklahoma City, Oklahoma, United States|35.46756,-97.51643
  • Charlottesville, Virginia, United States|38.02931,-78.47668

Key Eligibility Criteria

  • Participants who are at least 18 years of age on the day of signing informed consent with histologically confirmed diagnosis of Stage IVB cervical …
  • Patients with stage IVB adenocarcinoma, adenosquamous carcinoma, or squamous-cell carcinoma of the cervix that has not yet been treated with system…
  • Participants who have adverse events (AEs) due to previous anticancer therapies must have recovered to ≤ grade 1 or baseline. Participants with end…
  • The participant provides written informed consent for the trial

For full eligibility, visit ClinicalTrials.gov.

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