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NCT06540729
RC48 in Combination With AK104 and Bevacizumab in OCCC
Disitamab vedotin (RC48) in combination with AK104 (PD-1/CTLA-4 bispecific) and bevacizumab for the treatment of recurrent and persistent clear cell ovarian cancer: a single-arm, phase II, multicenter study (DAB OCC study)
Trial Details
NCT ID NCT06540729
Phase PHASE2
Sponsor Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Status RECRUITING
Cancer Type Ovarian Cancer
Interventions Disitamab vedotin in combination with AK104 and bevacizumab for the treatment of recurrent and persistent clear cell ovarian cancer
Locations (sample) Guanzhou, Guangdong, China|23.06828,113.37117
Key Eligibility Criteria
The pathological diagnosis confirms ovarian clear cell carcinoma. In cases of mixed carcinoma, a prerequisite is that clear cell carcinoma constitu… HER2 IHC ≥1+. Treatment-naïve individuals encompass those experiencing tumor progression during postoperative chemotherapy and those who, following platinum-cont… Recurrent patients, whether platinum-sensitive or platinum-resistant, include those lacking a platinum-free interval of ≥6 months and who, post-rec…
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