Radiotherapy Strategies for Use in Combined Treatment of Small-cell Lung Cancer

The purpose of this study is to evaluate the efficacy of radiotherapy as part of the combined treatment approach for patients diagnosed with histopathologically confirmed small cell lung cancer (SCLC) in the advanced stage of extensive disease (ED) who are undergoing chemo-immunotherapy. The planned study aims to assess the impact of incorporating consolidative radiotherapy into the treatment strategy, focusing on residual changes following chemo-immunotherapy (during immunotherapy) and its effect on progression-free survival. This research experiment will be conducted as a randomized multi-c

Trial Details

NCT ID
NCT06529081
Phase
NA
Sponsor
Copernicus Memorial Hospital
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Palliative Radiotherapy
  • Radical/Ablative Radiotherapy
Locations (sample)
  • Lublin, Poland|51.25058,22.57009
  • Lodz, Łódź Voivodeship, Poland|51.77058,19.47395

Key Eligibility Criteria

  • Histopathological confirmation of small cell lung cancer based on histological or cytological examination.
  • Primary clinical stage: Extensive stage of the disease according to VASLG classification or stage IV according to TNM classification.
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2 prior to randomization.
  • Partial response (PR) or stable disease (SD) to platinum-based doublet chemotherapy with durvalumab or atezolizumab based on restaging (positron em…

For full eligibility, visit ClinicalTrials.gov.

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