Feasibility of Primer Shot Radiotherapy for Non-small Cell Lung Cancer - PRIMER

Intro/rationale: Radiotherapy employs uniform, equally spaced weekday fractions that do not account for changes in tumor radiosensitivity. However, radiobiological characteristics evolve during the radiotherapy schedule as reoxygenation increases radiosensitivity. In tumor-response simulations and preclinical experiments, it was superior to prime the tumor with one radiotherapy fraction, followed by a treatment break permitting mitotic cell death and reoxygenation of tumor cells. Objective: To determine the safety and feasibility of primer shot fractionation for NSCLC. Study design: A prospe

Trial Details

NCT ID
NCT06528743
Phase
NA
Sponsor
The Netherlands Cancer Institute
Status
RECRUITING
Cancer Type
Non-Small Cell (NSCLC) Lung Cancer
Interventions
  • RT (5x6 Gy) to the primary tumor and, if indicated, to lymph node and/or distant metastases.
Locations (sample)
  • Amsterdam, Netherlands|52.37403,4.88969

Key Eligibility Criteria

  • Age ≥ 18 years
  • NSCLC (either pathology proven or sufficient clinical suspicion to be treated as NSCLC), referred for palliative radiotherapy of at least the prima…
  • WHO performance score 0-2.
  • Provision of signed, written and dated IC prior to any study specific procedures.

For full eligibility, visit ClinicalTrials.gov.

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