Randomized Phase II Trial: Chest Wall RT Omission After Prosthetic Reconstruction

The goal of this randomized Phase II clinical trial is to test the effects of omitting chest wall radiotherapy (RT) after prosthetic reconstruction in early-stage breast cancer patients. The main questions it aims to answer are: * Can omitting chest wall RT after prosthetic reconstruction reduce the failure rate of breast reconstruction without significantly increasing the local recurrence rate? * Does this approach ensure an improvement in the quality of life for patients without sacrificing therapeutic effectiveness? Participants will: * Be randomly assigned to one of two groups. * One gr

Trial Details

NCT ID
NCT06464913
Phase
PHASE2
Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Status
RECRUITING
Cancer Type
Breast Cancer
Interventions
  • With or without chest wall RT
Locations (sample)
  • Hangzhou, Zhejiang, China|30.29365,120.16142

Key Eligibility Criteria

  • Undergoes prosthetic reconstruction (including cold knife one-step prosthetic reconstruction or two-step expander-prosthetic reconstruction.);
  • Histologically confirmed invasive breast cancer patients with stage T1-2N1M0;
  • ECOG score of 0-1;
  • Indications for neoadjuvant therapy before surgery and adjuvant therapy after surgery.

For full eligibility, visit ClinicalTrials.gov.

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