OligoCare TwiCs (Trials Within Cohorts) Trial Comparing Acute Toxicity in Single-fraction vs Multiple-fraction SBRT for Metastasis-directed Treatment (SPRINT)

The goal of this clinical trial is to evaluate single-fraction metastases-directed SBRT in the broader radiation oncology community and to compare its safety and efficacy profile with the current Standard of Care (SoC) of multiple-fraction SBRT in patients with oligometastatic disease of primary breast, prostate, NSCLC and colorectal cancer having all lesions that will be treated with radical radiotherapy amenable to single-fraction SBRT. The main question/hypothesis this clinical trial aims to answer is: \- Single-fraction SBRT has comparable outcomes as those obtained with multiple fractio

Trial Details

NCT ID
NCT06462963
Phase
NA
Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • single-fraction SBRT
  • multiple-fraction SBRT
Locations (sample)
  • Aalst, Belgium|50.93604,4.0355
  • Brussels, Belgium|50.85045,4.34878
  • Ghent, Belgium|51.05,3.71667
  • Kortrijk, Belgium|50.82803,3.26487
  • Wilrijk, Belgium|51.16734,4.39513

Key Eligibility Criteria

  • Patient is part of the RP1822-OligoCare. As in OligoCare, ALL active cancer lesions (loco-regional primary and all oligometastases) were or will be…
  • All lesions that will be treated with radical radiotherapy have to be amenable to single-fraction SBRT. Concurrent systemic treatment is allowed.
  • Written informed consent must be given according to ICH/GCP, and national/local regulations. Patients will be consented in a step-wise approach.
  • Step 1 \[both control and experimental arms\]: patients will need to consent to be included and evaluated in E²-RADIatE (that includes the non-inte…

For full eligibility, visit ClinicalTrials.gov.

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