A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment

The goal of this clinical trial is to test the effect of high-dose radiation therapy after initial chemotherapy in patients with locally advanced pancreatic cancer. The main question it aims to answer is: • For patients with locally advanced pancreatic cancer that responded to initial chemotherapy (stayed stable or decreased in size), will high-dose RT (radiation therapy) contribute to improving treatment outcomes, enhancing quality of life, or increasing overall survival rates? Participants will: * Undergo an optional tumor biopsy. * Be treated with high dose radiation therapy. * Complete

Trial Details

NCT ID
NCT06453486
Phase
PHASE2
Sponsor
University Health Network, Toronto
Status
RECRUITING
Cancer Type
Pancreatic Cancer
Interventions
  • High dose radiation therapy
Locations (sample)
  • Toronto, Ontario, Canada|43.70643,-79.39864
  • Montreal, Quebec, Canada|45.50884,-73.58781

Key Eligibility Criteria

  • Have a histological or cytological diagnosis of LAPC.
  • Have pancreatic tumour \<8.0 cm in greatest axial dimension at the time of treatment planning but final determination of eligibility will be based …
  • Eastern Cooperative Oncology Group (ECOG) performance status ≤1 (Karnofsky ≥70%).
  • Life expectancy of greater than 6 months, as judged by the investigator.

For full eligibility, visit ClinicalTrials.gov.

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