Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

This phase I study aims to investigate the safety and efficacy of whole brain low dose radiotherapy (WB-LDRT) combined with ICI and intrathecal chemotherapy for treatment of refractory meningeal metastasis of lung cancer.

Trial Details

NCT ID
NCT06431685
Phase
PHASE1
Sponsor
Sichuan University
Status
RECRUITING
Cancer Type
Lung Cancer
Interventions
  • Whole Brain Low Dose Radiotherapy
  • Pemetrexed
  • Sintilimab
  • Chemotherapy
Locations (sample)
  • Chengdu, Sichuan, China|30.66667,104.06667

Key Eligibility Criteria

  • ≥ 18 years old and ≤ 75 years old;
  • Patients with a definite diagnosis of leptomeningeal metastasis by cerebrospinal fluid cytology, or patients with clinical diagnosis combined with …
  • Patients with a clear history of lung carcinoma, including histopathological diagnosis or a combination of cytopathology and imaging, and failure o…
  • Efficacy of extracranial lesions SD;

For full eligibility, visit ClinicalTrials.gov.

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