Risk Stratified De-escalated Hormone Therapy With Radiation Therapy for the Treatment of Prostate Cancer

This phase II trial tests how well risk based de-escalated hormone therapy (i.e., fewer treatments) with radiation works in treating patients with prostate cancer. Androgen deprivation therapy (ADT), such as gonadotropin-releasing hormone analogs (LHRH) and abiraterone acetate (Zytiga), lower the amount of the male hormone, testosterone, made by the body. This may help kill or stop the growth of tumor cells that need testosterone to grow. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Research has shown that long-term ADT is b

Trial Details

NCT ID
NCT06369610
Phase
PHASE2
Sponsor
Mayo Clinic
Status
RECRUITING
Cancer Type
Prostate Cancer
Interventions
  • Abiraterone Acetate
  • Biospecimen Collection
  • Computed Tomography
  • Gonadotropin-releasing Hormone Analog
  • Magnetic Resonance Imaging
  • Positron Emission Tomography
Locations (sample)
  • Scottsdale, Arizona, United States|33.50921,-111.89903

Key Eligibility Criteria

  • Histologically confirmed high risk prostate adenocarcinoma
  • Pathologic stages T1c-T4, N0-Nx-N1, M0-1 as staged by the pathology report (AJCC Criteria 8th Edition \[Ed\].)
  • One or more high risk features including Gleason 8-10, T3-T4, prostate specific antigen (PSA) ≥ 20
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2

For full eligibility, visit ClinicalTrials.gov.

Check If You May Be Eligible

Trialify translates complex eligibility criteria into plain yes-or-no questions to help you understand if this trial might be right for you.

Find Prostate Cancer Trials on Trialify →