Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly

Previous studies of this type of head and necl cancer have shown high rates of cancer control but result in many short and long term side effects when treated with high dose radiation and chemotherapy. Recently, investigators have noticed similar high rates of cancer control in small numbers of patients who receive less intensive treatments using lower doses of radiation, smaller radiation fields with chemotherapy. It is expected that the side effects of treatment with lower doses of radiation would be less. For this reason this study is looking at a different regimen of reducing the intensit

Trial Details

NCT ID
NCT06309225
Phase
NA
Sponsor
Omar Mahmoud
Status
RECRUITING
Cancer Type
Head and Neck Cancer
Interventions
  • Modified dose and fields intensity modulated radiotherapy
Locations (sample)
  • Jacksonville, Florida, United States|30.33218,-81.65565

Key Eligibility Criteria

  • Pathologically proven diagnosis of squamous cell carcinoma of the oropharynx (tonsil, base of tongue, soft palate, or oropharyngeal walls)
  • Patients must have clinically or radiographically evident measurable disease at the primary site or at nodal stations.
  • P16-positive based on local site immunohistochemical tissue staining
  • Clinical stage T1-3, N1-2, M0 (AJCC, 8th ed.)

For full eligibility, visit ClinicalTrials.gov.

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