Fluorescence Image Guided Surgery Followed by Intraoperative Photodynamic Therapy for Improving Local Tumor Control in Patients With Locally Advanced or Recurrent Colorectal Cancer

\*As of June 2026- Phase I has been completed and we are now in Phase II. This phase I/II trial studies the side effects and how well fluorescence image guided surgery followed by intraoperative photodynamic therapy for improving local tumor control in patients with colorectal cancer that has spread to nearby tissue or lymph nodes (locally advanced) or that has come back after a period of improvement (recurrent). Fluorescence image guided surgery uses a drug named aminolevulinic acid hydrochloride. Aminolevulinic acid hydrochloride is a photosensitizing agent, meaning that is activated by ligh

Trial Details

NCT ID

NCT06307548

Phase

PHASE1 / PHASE2

Sponsor

Roswell Park Cancer Institute

Status

RECRUITING

Cancer Type

Colon Cancer Colorectal Cancer

Interventions

Aminolevulinic Acid
Biospecimen Collection
Computed Tomography
Fluorescence-Guided Surgery
Magnetic Resonance Imaging
Photodynamic Therapy

Locations (sample)

Buffalo, New York, United States|42.88645,-78.87837

Key Eligibility Criteria

Age ≥ 18 years of age
Patients with locally advanced or recurrent colorectal cancer undergoing surgery
Amenable to diagnostic CT and MR imaging
Have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 3

For full eligibility, visit ClinicalTrials.gov.

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